منابع مشابه
Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis
DNA methylation has roles in different biological processes such as gene regulation and imprinting. In Arabidopsis, DNA is methylated in three cytosine contexts: CG, CHG and CHH (where H denotes A, T or C)1. In mammals, DNA is primarily methylated in CG contexts; however, studies have uncovered the presence of non-CG methylation in certain cell types such as embryonic stem cells and brain cells...
متن کاملRole of CG and Non-CG Methylation in Immobilization of Transposons in Arabidopsis
Methylation of cytosine residues in eukaryotic genomes is often associated with repeated sequences including transposons and their derivatives. Methylation has been implicated in control of two potential deleterious effects of these repeats: (1) uncontrolled transcription, which often disturbs proper expression of nearby host genes, and (2) changes in genome structure by transposition and ectop...
متن کاملRNAi, DRD1, and Histone Methylation Actively Target Developmentally Important Non-CG DNA Methylation in Arabidopsis
Cytosine DNA methylation protects eukaryotic genomes by silencing transposons and harmful DNAs, but also regulates gene expression during normal development. Loss of CG methylation in the Arabidopsis thaliana met1 and ddm1 mutants causes varied and stochastic developmental defects that are often inherited independently of the original met1 or ddm1 mutation. Loss of non-CG methylation in plants ...
متن کاملDNA Methylation Profiling Identifies CG Methylation Clusters in Arabidopsis Genes
Cytosine DNA methylation in vertebrates is widespread, but methylation in plants is found almost exclusively at transposable elements and repetitive DNA. Within regions of methylation, methylcytosines are typically found in CG, CNG, and asymmetric contexts. CG sites are maintained by a plant homolog of mammalian Dnmt1 acting on hemi-methylated DNA after replication. Methylation of CNG and asymm...
متن کاملTransgene-induced CCWGG methylation does not alter CG methylation patterning in human kidney cells
Several reports suggest that C(m)CWGG methylation tends not to co-exist with (m)CG methylation in human cells. We have asked whether or not methylation at CCWGG sites can influence CG methylation. DNA from cells expressing an M.EcoRII-GFP fusion was actively methylated at CCWGG sites. CG methylation as measured by R.HpaII/R.MspI ratios was unchanged in cells expressing the transgene. Cloned rep...
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ژورنال
عنوان ژورنال: Epigenetics
سال: 2010
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.5.7.12702